Samples

Agent

MIC/MBC (μg/mL)

FIC/FBC

FICI/FBCI²

Outcome

Alone

Combination¹

MSSA ATCC 25923³

Acacetin

5/20

1.25/5

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Oxacillin

0.25/1

0.0625/0.25

0.25/0.25

MRSA ATCC 33591⁴

Acacetin

20/40

5/10

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Oxacillin

8/16

2/4

0.25/0.25

MRSA 1⁵

Acacetin

10/40

2.5/10

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Oxacillin

16/32

4/8

0.25/0.25

MRSA 2

Acacetin

20/80

5/10

0.25/0.125

0.5/0.375

Synergistic/Synergistic

Oxacillin

8/16

2/4

0.25/0.25

MRSA 3

Acacetin

40/80

10/20

0.25/0.25

0.75/0.75

Additive/Additive

Oxacillin

8/16

4/8

0.5/0.5

MRSA 4

Acacetin

20/80

5/10

0.25/0.125

0.5/0.375

Synergistic/Additive

Oxacillin

16/32

4/8

0.25/0.25

MRSA 5

Acacetin

40/160

10/40

0.25/0.25

0.5/0.75

Synergistic/Additive

Oxacillin

16/32

4/16

0.25/0.5

MRSA 6

Acacetin

80/160

20/40

0.25/0.25

0.5/0.75

Synergistic/Additive

Oxacillin

8/16

2/8

0.25/0.5

MRSA 7

Acacetin

20/40

5/10

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Oxacillin

16/32

4/8

0.25/0.25

MRSA 8

Acacetin

10/20

5/10

0.5/0.5

0.75/0.375

Additive/Synergistic

Oxacillin

8/32

2/4

0.25/0.125

MRSA 9

Acacetin

10/40

2.5/5

0.25/0.125

0.75/0.375

Additive/Synergistic

Oxacillin

16/32

8/8

0.5/0.25

MRSA 10

Acacetin

40/80

10/20

0.25/0.25

0.75/0.75

Synergistic/Synergistic

Oxacillin

8/16

4/8

0.5/0.5

MRSA 11

Acacetin

20/80

5/20

0.25/0.25

0.5/0.375

Synergistic/Synergistic

Oxacillin

16/64

4/8

0.25/0.125

MRSA 12

Acacetin

80/160

20/40

0.25/0.25

0.375/0.5

Synergistic/Synergistic

Oxacillin

32/64

4/16

0.125/0.25

MRSA 13

Acacetin

80/160

20/80

0.25/0.5

0.375/0.75

Synergistic/Additive

Oxacillin

32/64

4/16

0.125/0.25

MRSA 14

Acacetin

40/80

10/20

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Oxacillin

16/32

4/8

0.25/0.25

MRSA 15

Acacetin

40/160

10/40

0.25/0.25

0.5/0.75

Synergistic/Additive

Oxacillin

8/16

2/8

0.25/0.5

MRSA 16

Acacetin

80/160

20/40

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Oxacillin

16/32

4/8

0.25/0.25

MRSA 17

Acacetin

10/20

2.5/10

0.25/0.5

0.5/1.0

Synergistic/Additive

Oxacillin

8/16

2/8

0.25/0.5

MRSA 18

Acacetin

80/160

20/40

0.25/0.25

0.5/0.5

Synergistic/Synergistic

Oxacillin

8/16

2/4

0.25/0.25

MRSA 19

Acacetin

80/160

20/40

0.25/0.25

0.5/0.375

Synergistic/Synergistic

Oxacillin

4/16

1/2

0.25/0.125

MRSA 20

Acacetin

40/80

10/20

0.25/0.25

0.5/0.75

Synergistic/Additive

Oxacillin

16/32

4/16

0.25/0.5